Science

脂質代謝物ライブラリー

脂質は、エネルギー源や生体膜成分として利用されるだけでなく、シグナル分子として宿主の生体機能に大きな影響を与えることが近年の研究により判ってきています。更に食事より摂取した脂質は、宿主が有する代謝を経て様々な脂肪酸代謝物に変換されるだけでなく、腸内細菌による代謝により、様々な修飾を受けることも判ってきています。
NOSTERは京都大学の小川順教授および岸野重信准教授らとの共同研究で、腸内細菌には宿主とは異なる脂質代謝経路が存在し、食事由来の脂質から特異な脂肪酸代謝物が産生され、多様な生理活性を有していることを見出しました^11）。現在、腸内細菌の脂質代謝を活用して、これらをオリジナルの脂質代謝物ライブラリーとして構築しており、新たな治療基盤の確立を目指しています。

Rational Formula	Abbreviation	Structural Formula	IUPAC Name	Molecular Weight	Chemical Formula
Rational Formula 10(OH)c12-18:1	Abbreviation HYA	Structural Formula	IUPAC Name 10-hydroxy-cis-12-octadecenoic acid	Molecular Weight 298.47	Chemical Formula C₁₈H₃₄O₃
Rational Formula 10(OH)t11-18:1	Abbreviation HYC	Structural Formula	IUPAC Name 10-hydroxy-trans-11-octadecenoic acid	Molecular Weight 298.47	Chemical Formula C₁₈H₃₄O₃
Rational Formula 10(OH)-18:0	Abbreviation HYB	Structural Formula	IUPAC Name 10-hydroxyoctadecanoic acid	Molecular Weight 300.48	Chemical Formula C₁₈H₃₆O₃
Rational Formula 10(oxo)c12-18:1	Abbreviation KetoA	Structural Formula	IUPAC Name 10-oxo-cis-12-octadecenoic acid	Molecular Weight 296.45	Chemical Formula C₁₈H₃₂O₃
Rational Formula 10(oxo)t11-18:1	Abbreviation KetoC	Structural Formula	IUPAC Name 10-oxo-trans-11-octadecenoic acid	Molecular Weight 296.45	Chemical Formula C₁₈H₃₂O₃
Rational Formula 10(oxo)-18:0	Abbreviation KetoB	Structural Formula	IUPAC Name 10-oxooctadecanoic acid	Molecular Weight 298.47	Chemical Formula C₁₈H₃₄O₃
Rational Formula c9,t11-18:2	Abbreviation CLA1	Structural Formula	IUPAC Name cis-9-trans-11-octadecadienoic acid	Molecular Weight 280.45	Chemical Formula C₁₈H₃₂O₂
Rational Formula t9,t11-18:2	Abbreviation CLA2	Structural Formula	IUPAC Name trans-9-trans-11-octadecadienoic acid	Molecular Weight 280.45	Chemical Formula C₁₈H₃₂O₂
Rational Formula t10,c12-18:2	Abbreviation CLA3	Structural Formula	IUPAC Name trans-10-cis-12-octadecadienoic acid	Molecular Weight 280.45	Chemical Formula C₁₈H₃₂O₂
Rational Formula t10-18:1	Abbreviation 10t	Structural Formula	IUPAC Name trans-10-octadecenoic acid	Molecular Weight 282.47	Chemical Formula C₁₈H₃₄O₂
Rational Formula 13(OH)c9-18:1	Abbreviation	Structural Formula	IUPAC Name 13-hydroxy-cis-9-octadecenoic acid	Molecular Weight 298.47	Chemical Formula C₁₈H₃₄O₃
Rational Formula 13(oxo)c9-18:1	Abbreviation	Structural Formula	IUPAC Name 13-oxo-cis-9-octadecenoic acid	Molecular Weight 296.45	Chemical Formula C₁₈H₃₂O₃
Rational Formula 10,13(diOH)-18:0	Abbreviation	Structural Formula	IUPAC Name 10,13-dihydroxyoctadecanoic acid	Molecular Weight 316.48	Chemical Formula C₁₈H₃₆O₄
Rational Formula 10(OH)c12,c15-18:2	Abbreviation αHYA	Structural Formula	IUPAC Name 10-hydroxy-cis-12-cis-15-octadecadienoic acid	Molecular Weight 296.45	Chemical Formula C₁₈H₃₂O₃
Rational Formula 10(OH)t11,c15-18:2	Abbreviation αHYC	Structural Formula	IUPAC Name 10-hydroxy-trans-11-cis-15-octadecadienoic acid	Molecular Weight 296.45	Chemical Formula C₁₈H₃₂O₃
Rational Formula 10(OH)c15-18:1	Abbreviation αHYB	Structural Formula	IUPAC Name 10-hydroxy-cis-15-octadecenoic acid	Molecular Weight 298.47	Chemical Formula C₁₈H₃₄O₃
Rational Formula 10(oxo)c12,c15-18:2	Abbreviation αKetoA	Structural Formula	IUPAC Name 10-oxo-cis-12-cis-15-octadecadienoic acid	Molecular Weight 294.44	Chemical Formula C₁₈H₃₀O₃
Rational Formula 10(oxo)t11,c15-18:2	Abbreviation αKetoC	Structural Formula	IUPAC Name 10-oxo-trans-11-cis-15-octadecadienoic acid	Molecular Weight 294.44	Chemical Formula C₁₈H₃₀O₃
Rational Formula 10(oxo)c15-18:1	Abbreviation αKetoB	Structural Formula	IUPAC Name 10-oxo-cis-15-octadecenoic acid	Molecular Weight 296.45	Chemical Formula C₁₈H₃₂O₃
Rational Formula c9,t11,c15-18:3	Abbreviation CALA1	Structural Formula	IUPAC Name cis-9-trans-11-cis-15-octadecatrienoic acid	Molecular Weight 278.44	Chemical Formula C₁₈H₃₀O₂
Rational Formula t9,t11,c15-18:3	Abbreviation CALA2	Structural Formula	IUPAC Name trans-9-trans-11-cis-15-octadecatrienoic acid	Molecular Weight 278.44	Chemical Formula C₁₈H₃₀O₂
Rational Formula t10,c12,c15-18:3	Abbreviation CALA3	Structural Formula	IUPAC Name trans-10-cis-12-cis-15-octadecatrienoic acid	Molecular Weight 278.44	Chemical Formula C₁₈H₃₀O₂

Rational Formula

Abbreviation

Structural Formula

IUPAC Name

Molecular Weight

Chemical Formula

Rational Formula

10(OH)c12-18:1

Abbreviation

HYA

Structural Formula

IUPAC Name

10-hydroxy-cis-12-octadecenoic acid

Molecular Weight

298.47

Chemical Formula

C₁₈H₃₄O₃

Rational Formula

10(OH)t11-18:1

Abbreviation

HYC

Structural Formula

IUPAC Name

10-hydroxy-trans-11-octadecenoic acid

Molecular Weight

298.47

Chemical Formula

C₁₈H₃₄O₃

Rational Formula

10(OH)-18:0

Abbreviation

HYB

Structural Formula

IUPAC Name

10-hydroxyoctadecanoic acid

Molecular Weight

300.48

Chemical Formula

C₁₈H₃₆O₃

Rational Formula

10(oxo)c12-18:1

Abbreviation

KetoA

Structural Formula

IUPAC Name

10-oxo-cis-12-octadecenoic acid

Molecular Weight

296.45

Chemical Formula

C₁₈H₃₂O₃

Rational Formula

10(oxo)t11-18:1

Abbreviation

KetoC

Structural Formula

IUPAC Name

10-oxo-trans-11-octadecenoic acid

Molecular Weight

296.45

Chemical Formula

C₁₈H₃₂O₃

Rational Formula

10(oxo)-18:0

Abbreviation

KetoB

Structural Formula

IUPAC Name

10-oxooctadecanoic acid

Molecular Weight

298.47

Chemical Formula

C₁₈H₃₄O₃

Rational Formula

c9,t11-18:2

Abbreviation

CLA1

Structural Formula

IUPAC Name

cis-9-trans-11-octadecadienoic acid

Molecular Weight

280.45

Chemical Formula

C₁₈H₃₂O₂

Rational Formula

t9,t11-18:2

Abbreviation

CLA2

Structural Formula

IUPAC Name

trans-9-trans-11-octadecadienoic acid

Molecular Weight

280.45

Chemical Formula

C₁₈H₃₂O₂

Rational Formula

t10,c12-18:2

Abbreviation

CLA3

Structural Formula

IUPAC Name

trans-10-cis-12-octadecadienoic acid

Molecular Weight

280.45

Chemical Formula

C₁₈H₃₂O₂

Rational Formula

t10-18:1

Abbreviation

10t

Structural Formula

IUPAC Name

trans-10-octadecenoic acid

Molecular Weight

282.47

Chemical Formula

C₁₈H₃₄O₂

Rational Formula

13(OH)c9-18:1

Abbreviation

Structural Formula

IUPAC Name

13-hydroxy-cis-9-octadecenoic acid

Molecular Weight

298.47

Chemical Formula

C₁₈H₃₄O₃

Rational Formula

13(oxo)c9-18:1

Abbreviation

Structural Formula

IUPAC Name

13-oxo-cis-9-octadecenoic acid

Molecular Weight

296.45

Chemical Formula

C₁₈H₃₂O₃

Rational Formula

10,13(diOH)-18:0

Abbreviation

Structural Formula

IUPAC Name

10,13-dihydroxyoctadecanoic acid

Molecular Weight

316.48

Chemical Formula

C₁₈H₃₆O₄

Rational Formula

10(OH)c12,c15-18:2

Abbreviation

αHYA

Structural Formula

IUPAC Name

10-hydroxy-cis-12-cis-15-octadecadienoic acid

Molecular Weight

296.45

Chemical Formula

C₁₈H₃₂O₃

Rational Formula

10(OH)t11,c15-18:2

Abbreviation

αHYC

Structural Formula

IUPAC Name

10-hydroxy-trans-11-cis-15-octadecadienoic acid

Molecular Weight

296.45

Chemical Formula

C₁₈H₃₂O₃

Rational Formula

10(OH)c15-18:1

Abbreviation

αHYB

Structural Formula

IUPAC Name

10-hydroxy-cis-15-octadecenoic acid

Molecular Weight

298.47

Chemical Formula

C₁₈H₃₄O₃

Rational Formula

10(oxo)c12,c15-18:2

Abbreviation

αKetoA

Structural Formula

IUPAC Name

10-oxo-cis-12-cis-15-octadecadienoic acid

Molecular Weight

294.44

Chemical Formula

C₁₈H₃₀O₃

Rational Formula

10(oxo)t11,c15-18:2

Abbreviation

αKetoC

Structural Formula

IUPAC Name

10-oxo-trans-11-cis-15-octadecadienoic acid

Molecular Weight

294.44

Chemical Formula

C₁₈H₃₀O₃

Rational Formula

10(oxo)c15-18:1

Abbreviation

αKetoB

Structural Formula

IUPAC Name

10-oxo-cis-15-octadecenoic acid

Molecular Weight

296.45

Chemical Formula

C₁₈H₃₂O₃

Rational Formula

c9,t11,c15-18:3

Abbreviation

CALA1

Structural Formula

IUPAC Name

cis-9-trans-11-cis-15-octadecatrienoic acid

Molecular Weight

278.44

Chemical Formula

C₁₈H₃₀O₂

Rational Formula

t9,t11,c15-18:3

Abbreviation

CALA2

Structural Formula

IUPAC Name

trans-9-trans-11-cis-15-octadecatrienoic acid

Molecular Weight

278.44

Chemical Formula

C₁₈H₃₀O₂

Rational Formula

t10,c12,c15-18:3

Abbreviation

CALA3

Structural Formula

IUPAC Name

trans-10-cis-12-cis-15-octadecatrienoic acid

Molecular Weight

278.44

Chemical Formula

C₁₈H₃₀O₂

…

Total > 300

（引用文献）
11) Kishino, S. et al. Proc Natl Acad Sci USA 29, 17808-17813 (2013).

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