A collaborative research team from the University of Shizuoka, Kobe University, and Noster Inc. has discovered that HYA (10-hydroxy-cis-12-octadecenoic acid), a metabolite produced by gut bacteria from dietary linoleic acid, suppresses adipocyte hypertrophy by activating AMPK within fat cells.
These findings suggest that HYA may offer a new therapeutic approach for obesity and metabolic disorders.
The results of this study have been published in the international journal Nutrients.
Reference
Matsushita R, Sato K, Uchida K, Imi Y, Amano R, Kasahara N, Kitao Y, Oishi Y, Kawaai H, Tomimoto C, et al. A Gut Microbial Metabolite HYA Ameliorates Adipocyte Hypertrophy by Activating AMP-Activated Protein Kinase. Nutrients, 2025; 17(8):1393.
https://doi.org/10.3390/nu17081393
