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Microbiome analysis

NOSTER employs hybrid analysis of the gut microbiome that combines our unique in-house culture technology with gut microbe metagenomics analysis utilizing next-generation sequencing.
By combining the molecular biological approach to analyze the occupancy rate of each gut microbe with next-generation sequencing and our unique technology to culture anaerobic bacteria (Akkermansia, Bacteroides, Bifidobacterium, Blautia, Clostridium etc.) it is now possible to quantitively analyze the cell count per weight of feces. Notably, this hybrid, qualitative and quantitative analysis enables a much more detailed understanding of the microbiome that could not be achieved by existing metagenomic analysis alone.
Recent scientific reports show that gut microbes affect metabolic diseases including obesity and type 2 diabetes 1-4), inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease 5, 6), and even mental disorders such as autism 7).
NOSTER is promoting international open science research with academia to identify gut microbes associated with diseases, with the goal of realizing revolutionary and innovative medical therapeutics powered by gut-microbe drug discovery.

Reference
1) Ley, R.E. et al. Proc Natl Acad Sci USA 102, 11070-11075 (2005).
2) Turnbaugh, P.J. et al. Cell Host Microbe 3, 213-223 (2008).
3) Yoshimoto, S. et al. Nature 499, 97-101 (2013).
4) Wen, L. et al. Nature 455, 1109-1113 (2008).
5) Png, C.W. et al. Am J Gastroenterol 105, 2420-2428 (2010).
6) Li, Q. et al. PLoS One 7, e34939 (2012).
7) Finegold, S.M. et al. Anaerobe 16, 444-453 (2010).

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  • NOSTER | Science Microbiome Prize