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INTERVIEWHYA™ improves the intestinal barrier function and prevents obesity and diabetes

Professor, Department of Internal Medicine (Nephrology, Endocrinology and Metabolism), Keio University School of MedicineHIROSHI ITOH

Completed doctoral course at Kyoto University Graduate School of Medicine (Doctor of Medicine) in 1989. After working as a researcher at Harvard Medical School in the United States and Stanford University School of Medicine in the United States, he is currently a professor at the Department of Nephrology, Endocrinology and Metabolism, Keio University School of Medicine. He is also the director of the University's Diabetes Preemptive Medicine Center and the deputy director of the Center for Centenarian Research. He is a former representative director of the Japan Endocrine Society.

Protecting the body from inflammation with the hidden power of the gut

The intestines efficiently absorb sugar, amino acids and other substances necessary for the body from the food you eat. In fact, the intestine not only absorbs nutrients, but also protects the body from harmful substances. If this function, known as the 'intestinal barrier', is compromised, harmful substances and bacteria contained in food can easily enter the body, leading to a condition known as 'inflammation'. More recently, it has been found that obese and diabetic people have a reduced intestinal barrier function, which makes it easier for harmful substances to enter the body.

The intestinal barrier is the defense barrier against obesity and diabetes

Although the link between obesity and diabetes and inflammation has been known for some time, the causes were unknown. We discovered a cause-and-effect relationship: 'When you eat a fatty diet, the intestinal barrier function is impaired and more harmful substances enter the body, resulting in inflammation, which leads to obesity and diabetes'. Furthermore, we found that 'when the intestinal barrier is strengthened, diabetes does not occur even if a fatty diet is consumed'. Our research has shown that before lipid disorders and hyperglycaemia occur, the intestinal dysfunction should first be prevented.

HYA™ strengthens the intestinal barrier and prevents obesity and diabetes

The barrier function of the gut is essential for the body. This is supported by the gut microbes. For people with obesity and diabetes, the gut microbiota are out of balance and their ability to maintain intestinal health is reduced, making it easier for harmful substances to enter the body. One such substance produced by intestinal bacteria that supports intestinal function is HYA™. In fact, basic research has shown that HYA™ strengthens the intestinal barrier function and that HYA™ prevents obesity and diabetes.

Further research on HYA™ is being undertaken for the development of treatments for obesity and diabetes

After basic research, studies in healthy humans have shown that "taking HYA™ prevents blood glucose from rising and reduces weight". Currently, more advanced research is being conducted on how obese people can benefit from taking HYA™ and whether it improves the intestinal barrier function. As there is still no fundamental cure, the number of people with obesity and diabetes is increasing worldwide. I strongly hope that improving the condition of the gut with HYA™ will lead to advances in the prevention and treatment of obesity and diabetes.

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