2020.11.02
Gut microbes
More than 1,000 species including over 100 trillion gut microbes coexist and form varieties of microorganism-ecosystems …
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Lipid metabolite library
Recent studies shows that lipids are not only used as energy sources and biomembrane components, but also have a significant effect on host biological functions as signal molecules. Furthermore, it is known that the lipids ingested from the diet are not only converted into various fatty acid metabolites by metabolism of the host, but also undergo a variety of modifications by metabolism of the gut microbes.
A collaboration between NOSTER and Professor Jun Ogawa and Associate Professor Shigenobu Kishino at Kyoto University, showed that metabolic pathways exist in lipids that are different from ones in the host, and that produce special fatty acid metabolites from dietary lipids, which have many kinds of physiological activity 11). We are currently constructing an original lipid metabolite library by utilizing the lipid metabolism pathways of gut microbes with the aim of establishing a new therapeutic discipline.
| Rational Formula | Abbreviation | Structural Formula | IUPAC Name | Molecular Weight | Chemical Formula |
|---|---|---|---|---|---|
Rational Formula10(OH)c12-18:1 |
AbbreviationHYA |
Structural Formula
|
IUPAC Name10-hydroxy-cis-12-octadecenoic acid |
Molecular Weight298.47 |
Chemical FormulaC18H34O3 |
Rational Formula10(OH)t11-18:1 |
AbbreviationHYC |
Structural Formula
|
IUPAC Name10-hydroxy-trans-11-octadecenoic acid |
Molecular Weight298.47 |
Chemical FormulaC18H34O3 |
Rational Formula10(OH)-18:0 |
AbbreviationHYB |
Structural Formula
|
IUPAC Name10-hydroxyoctadecanoic acid |
Molecular Weight300.48 |
Chemical FormulaC18H36O3 |
Rational Formula10(oxo)c12-18:1 |
AbbreviationKetoA |
Structural Formula
|
IUPAC Name10-oxo-cis-12-octadecenoic acid |
Molecular Weight296.45 |
Chemical FormulaC18H32O3 |
Rational Formula10(oxo)t11-18:1 |
AbbreviationKetoC |
Structural Formula
|
IUPAC Name10-oxo-trans-11-octadecenoic acid |
Molecular Weight296.45 |
Chemical FormulaC18H32O3 |
Rational Formula10(oxo)-18:0 |
AbbreviationKetoB |
Structural Formula
|
IUPAC Name10-oxooctadecanoic acid |
Molecular Weight298.47 |
Chemical FormulaC18H34O3 |
Rational Formulac9,t11-18:2 |
AbbreviationCLA1 |
Structural Formula
|
IUPAC Namecis-9-trans-11-octadecadienoic acid |
Molecular Weight280.45 |
Chemical FormulaC18H32O2 |
Rational Formulat9,t11-18:2 |
AbbreviationCLA2 |
Structural Formula
|
IUPAC Nametrans-9-trans-11-octadecadienoic acid |
Molecular Weight280.45 |
Chemical FormulaC18H32O2 |
Rational Formulat10,c12-18:2 |
AbbreviationCLA3 |
Structural Formula
|
IUPAC Nametrans-10-cis-12-octadecadienoic acid |
Molecular Weight280.45 |
Chemical FormulaC18H32O2 |
Rational Formulat10-18:1 |
Abbreviation10t |
Structural Formula
|
IUPAC Nametrans-10-octadecenoic acid |
Molecular Weight282.47 |
Chemical FormulaC18H34O2 |
Rational Formula13(OH)c9-18:1 |
Abbreviation |
Structural Formula
|
IUPAC Name13-hydroxy-cis-9-octadecenoic acid |
Molecular Weight298.47 |
Chemical FormulaC18H34O3 |
Rational Formula13(oxo)c9-18:1 |
Abbreviation |
Structural Formula
|
IUPAC Name13-oxo-cis-9-octadecenoic acid |
Molecular Weight296.45 |
Chemical FormulaC18H32O3 |
Rational Formula10,13(diOH)-18:0 |
Abbreviation |
Structural Formula
|
IUPAC Name10,13-dihydroxyoctadecanoic acid |
Molecular Weight316.48 |
Chemical FormulaC18H36O4 |
Rational Formula10(OH)c12,c15-18:2 |
AbbreviationαHYA |
Structural Formula
|
IUPAC Name10-hydroxy-cis-12-cis-15-octadecadienoic acid |
Molecular Weight296.45 |
Chemical FormulaC18H32O3 |
Rational Formula10(OH)t11,c15-18:2 |
AbbreviationαHYC |
Structural Formula
|
IUPAC Name10-hydroxy-trans-11-cis-15-octadecadienoic acid |
Molecular Weight296.45 |
Chemical FormulaC18H32O3 |
Rational Formula10(OH)c15-18:1 |
AbbreviationαHYB |
Structural Formula
|
IUPAC Name10-hydroxy-cis-15-octadecenoic acid |
Molecular Weight298.47 |
Chemical FormulaC18H34O3 |
Rational Formula10(oxo)c12,c15-18:2 |
AbbreviationαKetoA |
Structural Formula
|
IUPAC Name10-oxo-cis-12-cis-15-octadecadienoic acid |
Molecular Weight294.44 |
Chemical FormulaC18H30O3 |
Rational Formula10(oxo)t11,c15-18:2 |
AbbreviationαKetoC |
Structural Formula
|
IUPAC Name10-oxo-trans-11-cis-15-octadecadienoic acid |
Molecular Weight294.44 |
Chemical FormulaC18H30O3 |
Rational Formula10(oxo)c15-18:1 |
AbbreviationαKetoB |
Structural Formula
|
IUPAC Name10-oxo-cis-15-octadecenoic acid |
Molecular Weight296.45 |
Chemical FormulaC18H32O3 |
Rational Formulac9,t11,c15-18:3 |
AbbreviationCALA1 |
Structural Formula
|
IUPAC Namecis-9-trans-11-cis-15-octadecatrienoic acid |
Molecular Weight278.44 |
Chemical FormulaC18H30O2 |
Rational Formulat9,t11,c15-18:3 |
AbbreviationCALA2 |
Structural Formula
|
IUPAC Nametrans-9-trans-11-cis-15-octadecatrienoic acid |
Molecular Weight278.44 |
Chemical FormulaC18H30O2 |
Rational Formulat10,c12,c15-18:3 |
AbbreviationCALA3 |
Structural Formula
|
IUPAC Nametrans-10-cis-12-cis-15-octadecatrienoic acid |
Molecular Weight278.44 |
Chemical FormulaC18H30O2 |
Reference
11) Kishino, S. et al. Proc Natl Acad Sci USA 29, 17808-17813 (2013).
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